Genetic Dissection of Health and Disease at Single Cell Resolution with MADM
To study how neural stem cells divide at single cell resolution I use a powerful genetic platform called Mosaic Analysis With Double Markers (MADM). Here is an example of a brain section where the green, red, and yellow cells label MADM recombination events. The blue (DAPI) labels the nuclear DNA of cells. Try zooming in to explore this sample. Can you identify some of the different cell types that are present in the brain such as neurons, oligodendrocytes and astrocytes?For more information regarding the genetics involved in MADM technology, please see the MADM Principle page.
Please explore other regions of the MADM labelled brain by selecting a region of interest below.
